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作者着重研究发病期间未用神经阻滞药治疗的抑郁症患者ECT全过程的催乳素(PRL)释放。方法:10名受试者,女6例,男4例,平均年龄56.3岁,均符合RDC重性抑郁障碍标准,且无任何严重的躯体疾病。受试前3月内,未接受ECT及神经阻滞药。首次ECT时,5例接受三环抗抑郁药,2例用碳酸锂,1例用水合氯醛、1例用雷尼替丁、1例未用药,整个ECT治疗过程中,药物治疗不变。硫喷妥钠麻醉后给予琥珀酰胆碱,剂量始终不变。用短暂脉冲式恒定电流ECT仪提供刺激(800mA,5秒),电极放置:3例单侧,7例双侧。以6导便携式EEG仪记录癫癎发作活动。ECT前60分钟插入静脉内导管,并于
The author focuses on the release of prolactin (PRL) throughout the course of ECT in patients with depression who have not been treated with neuroleptics during the onset of disease. Methods: Ten subjects, 6 females, 4 males and a mean age of 56.3 years, all of whom were in line with the criteria of major depressive disorder of RDC without any serious somatic diseases. Within 3 months before the test, ECT and nerve block drugs were not accepted. At the first ECT, medication was unchanged in 5 patients receiving tricyclic antidepressants, 2 in lithium carbonate, 1 in chloral hydrate, 1 in ranitidine, and 1 in nonuse of ECT. Supratechine was given to anesthetize and the dose remained unchanged. Stimulation (800 mA for 5 seconds) was provided with a brief pulsed constant current ECT instrument, with the electrodes placed on three unilateral and seven bilateral sides. Epileptic seizures were recorded on a 6-lead portable EEG instrument. 60 minutes before ECT into the intravenous catheter, and at