急性冠状动脉综合征(ACS)的发生多是在不稳定斑块出现裂缝、糜烂或破裂的基础上,形成血栓,导致急性心肌缺血。因其发病急,常导致严重心脏事件而受到特别关注。目前认为,ACS的发病基础取决于斑块的稳定性而不是动脉管腔狭窄的严重程度。寻求新型敏感的特异性的斑块不稳定性标志物比传统的危险因子能够更好的预测ACS,如红细胞膜胆固醇、基质金属蛋白酶及髓过氧化物酶,对ACS的危险分层及治疗均有重要的意义。 Acute coronary syndrome (ACS) occurs mostly in the unstable plaque cracks, erosion or rupture, based on the formation of thrombus, leading to acute myocardial ischemia. Because of its acute onset, often lead to serious cardiac events and receive particular attention. It is currently believed that the basis of the onset of ACS depends on the stability of the plaque rather than the severity of arterial stenosis. The search for novel, sensitive, and specific plaque instability markers is a better predictor of ACS than traditional risk factors such as erythrocyte membrane cholesterol, matrix metalloproteinase and myeloperoxidase, risk stratification and treatment of ACS Is of great significance.