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OBJECTIVE Using formulation analysis to ensure the formulation quality of paracetamol suspension prepared for primate toxicity study.METHODS 25% PEG 400 was employed to prepare different paracetamol suspension.HPLC method was established to monitor prepared formulation concentrations.RESULTS ① for the fresh prepared 90mg/ml suspension, the actual concentration was only 88.8% of nominal concentration (79.9 g· L-1).The situation could be improved by 24 h continue stirring.After that, the actual concentration tested was 94.2% of nominal concentration, which met the accept criteria.② It was found different sampling methods may influence formulation analysis results of paracetamol suspension.Electronic pipettes got lower tested concentration than transfer pipettes (82.8% vs 101.7%).CONCLUSION Both the formulation (stirring) and sampling method have impact on formulation quality.