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目的:探讨影响结核病感染患者预后的相关因素。方法:选取本院2010年1月至2013年12月收治的肺结核感染患者84例为研究对象,采用单因素分析影响肺结核患者预后的相关因素,同时采用Cox回归分析患者预后独立危险因素,并采用Kaplan-Meier法计算患者累计生存率。结果:经单因素分析可知,影响肺结核患者预后的因素包括呼年龄、患病时间、吸烟、是否行机械通气、是否接受规则抗结核治疗、呼吸衰竭II型、APACHEII>25分、肝损害、合并真菌感染、合并基础疾病。经Cox多因素回归分析可知,呼吸衰竭II型(OR=3.066,95%CI 1.021-7.298))、APACHEII>25分(OR=1.984,95%CI 1.021-5.201)、合并真菌感染(OR=1.658,95%CI 1.187-3.964)、肝损害(OR=1.587,95%CI 1.085-3.412)、合并基础疾病(1.623,95%CI 1.045-4.369)是影响患者预后的独立危险因子。结论:影响结核感染疾病预后的因素包括呼吸衰竭II型、APACHEII>25分、合并真菌感染、肝损害,这些因素可增加患者病死率,降低患者生存质量。
Objective: To explore the factors that affect the prognosis of patients with tuberculosis infection. Methods: Totally 84 patients with tuberculosis infection admitted to our hospital from January 2010 to December 2013 were enrolled in this study. Univariate analysis was used to analyze the prognostic factors in patients with pulmonary tuberculosis. At the same time, Cox regression was used to analyze the prognostic independent risk factors, Kaplan-Meier method to calculate the cumulative survival rate of patients. Results: According to univariate analysis, the factors influencing the prognosis of patients with pulmonary tuberculosis include age of onset, duration of illness, smoking, mechanical ventilation, regular anti-tuberculosis treatment, respiratory failure type II, APACHEII> 25, liver damage, merger Fungal infections, with underlying diseases. Cox regression analysis showed that respiratory failure type II (OR = 3.066,95% CI 1.021-7.298), APACHEII> 25 points (OR = 1.984,95% CI 1.021-5.201), combined fungal infection (OR = 1.658 , 95% CI 1.187-3.964), liver damage (OR = 1.587,95% CI 1.085-3.412), and underlying diseases (1.623,95% CI 1.045-4.369) were independent risk factors affecting the prognosis of patients. CONCLUSION: The factors that affect the prognosis of tuberculosis infection include respiratory failure type II, APACHEII> 25, combined fungal infection and liver damage. These factors can increase the mortality and reduce the quality of life of patients.