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以某制药厂含有机酸凝结水为研究对象,建立了气质联用(GC-MS)测定有机酸的方法,研究了不同的进样方式及pH条件对离子交换萃取效率的影响。研究结果表明:GC-MS检测得到凝结水中含有甲酸、乙酸、丙酸、丁酸、戊酸、己酸、异丁酸和2-甲基丁酸8种有机酸,GC-MS能将这8种有机酸完全分开;GC-MS检测得到标准曲线线性为:0.999、0.999、0.999、0.999、0.999 8、0.999 8、0.999 7、0.999 2,标准偏差分别为0.05、0.09、0.05、0.02、0.02、0.05、0.06、0.06;调节水样pH值为7且进样0.2 mL时有机酸的回收率分别为92.55%、83.48%、92.38%、101.4%、93.82%、97.24%、92.87%、93.81%。
A method for determination of organic acids by gas chromatography-mass spectrometry (GC-MS) was established to study the effect of different injection methods and pH conditions on the efficiency of ion exchange extraction. The results showed that GC-MS could detect 8 kinds of organic acids including formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, isobutyric acid and 2-methylbutyric acid The organic acids were completely separated. The linearity of the standard curve obtained by GC-MS was 0.999,0.999,0.999,0.999,0.999 8,0.999 8,0.999 7,0.999 2, the standard deviations were 0.05,0.09,0.05,0.02,0.02, 0.05, 0.06, 0.06 respectively. The recoveries of organic acids were 92.55%, 83.48%, 92.38%, 101.4%, 93.82%, 97.24%, 92.87%, 93.81% when the pH value of water sample was adjusted to 7 and 0.2 mL was injected.