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目的:探讨Survivin基因的表达在小儿急性白血病发病过程中的意义。方法:将45例小儿急性白血病患者设为观察组,将同期22例健康体检患儿设为对照组,均实施Survivin基因的PCR检测,比较两组Survivin基因的表达水平;并根据Survivin基因水平将观察组分为阳性表达组(33例)及阴性表达组(12例),比较两组的早期疗效缓解情况。结果:观察组Survivin基因阳性表达率为73.3%,显著高于对照组的22.7%(P<0.05);且小儿急性白血病患儿中,Survivin阳性表达组早期疗效缓解率为15.2%,显著低于Survivin阴性表达组的66.7%(P<0.05)。结论:Survivin水平的检测可成为小儿急性白血病的有效诊断依据,且对发病过程的评估有指导意义。
Objective: To investigate the significance of Survivin gene expression in the pathogenesis of childhood acute leukemia. Methods: Forty-five children with acute leukemia were enrolled in the observation group and 22 healthy children in the same period were enrolled as the control group. The Survivin gene was detected by PCR. Survivin gene expression was compared between the two groups. According to the Survivin gene level The observation group consisted of positive expression group (33 cases) and negative expression group (12 cases), and the early treatment response was compared between the two groups. Results: The positive expression rate of Survivin gene in observation group was 73.3%, which was significantly higher than that in control group (22.7%, P <0.05). In children with acute leukemia, the early response rate of Survivin positive group was 15.2% Survivin negative expression group 66.7% (P <0.05). Conclusion: The detection of Survivin level can be an effective diagnostic basis for pediatric acute leukemia, and it is instructive to evaluate the course of the disease.