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目的:制备盐酸西替利嗪缓释制剂以验证其缓释制剂延长药效的作用。方法:通过建立大白鼠异种血清对小鼠耳异种被动皮肤过敏反应所引起的血管通透性增强的模型,给予盐酸西替利嗪缓释制剂,试验验证其药效学。结果:盐酸西替利嗪缓释剂组与空白组、阳性对照组对比药效维持时间显著延长,表明其抗过敏作用时间延长,有明显缓释效果。结论:盐酸西替利嗪缓释制剂释药缓慢、效果显著,有很好的发展前景。
OBJECTIVE: To prepare cetirizine hydrochloride sustained-release preparation to verify the effect of extended-release preparation on prolonged efficacy. Methods: The model of celecoxib hydrochloride sustained release preparation was established by establishing the model of rat vascular endothelial cell hypersensitivity reaction induced by heterologous serum in mice, and its pharmacodynamics was tested. Results: Compared with the blank group and the positive control group, the sustained-release efficacy of the cetirizine hydrochloride sustained-release agent group was significantly prolonged, indicating that the anti-allergic effect was prolonged and the sustained release effect was obvious. Conclusion: The cetirizine hydrochloride sustained-release preparation has slow release and remarkable effect with good development prospects.