氯丙咪嗪是治疗强迫症及抑郁症的首选药物之一。现将临床所见两例大剂量氯丙咪嗪引起癫痫大发作报告如下:例一,患者,女性,16岁,住院号90—440。以“反复思考,反复洗手,反复提裤子半年”为主诉,于1990年9月16日首次住院,既往无脑外伤,抽搐病史。体检:无阳性体征发现。实验室检查报告均正常。精神检查:神志清,仪表整洁,情绪低。住院诊断“强迫性神经症”,因无氯丙咪嗪药物,暂给以小剂量氯氮平药物治疗。10月9日开始给用国产氯丙咪嗪100mg/日,渐渐加量,10天内加到250mg/日用药10天,强迫动作消失。用药20 Clomipramine is the treatment of obsessive-compulsive disorder and depression, one of the preferred drugs. Now see the clinical findings of two cases of large doses of clomipramine epilepsy seizures reported as follows: First, the patient, female, 16 years old, hospital number 90-440. To “repeatedly thinking, repeated hand-washing, repeated mention pants six months” as the chief complaint, on September 16, 1990 the first hospitalization, previous history of brain injury, convulsions. Physical examination: No positive signs found. Laboratory test reports are normal. Mental examination: Consciousness, tidy instrument, low mood. Inpatient diagnosis of “obsessive-compulsive neurosis”, due to clomipramine drug, temporarily to a small dose of clozapine drug treatment. October 9 began to use domestic clomipramine 100mg / day, gradually increase the amount of 10 days added to 250mg / day medication for 10 days, forced action disappeared. Medication 20