作者用体内外两种方法在印度阿萨姆邦的15个村庄测定当地恶性疟原虫对氯喹的敏感性。体内测定法采用WHO推荐的28天延长法,共测定20例,除2例未完成追踪随访外,其中Ⅰ级抗性6例,Ⅱ级抗性5例,Ⅲ级抗性2例,敏感5例。19例在D-3用Dill及Glazko法作尿测定,证明氯喹吸收良好,1例未测。体外测定用两种不同的方法进行。一种 The authors tested the susceptibility of native Plasmodium falciparum to chloroquine in 15 villages in Assam, India, in vitro and in vivo. The in vivo assay was based on the 28-day extension method recommended by the WHO, and a total of 20 cases were examined. Except for 2 cases, 6 cases were grade Ⅰ, 5 cases were grade Ⅱ, 2 cases were grade Ⅲ, and 5 cases were sensitive example. Nineteen patients underwent Dill and Glazko’s urinalysis at D-3, demonstrating that chloroquine was well absorbed and none was detected. In vitro assays were performed using two different methods. A