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目的研究马来酸曲美布汀联合双歧杆菌四连活菌片治疗肠易激综合征的临床疗效。方法将117例肠易激综合征患者随机分为治疗组60例和对照组57例。治疗组采用马来酸曲美布汀100mg,3次/d口服,双歧杆菌四连活菌片1.5g,3次/d口服;对照组仅采用马来酸曲美布汀100mg,3次/d口服。疗程均为4周。结果治疗组总有效率为95.0,对照组总有效率为80.7。治疗组总有效率明显优于对照组(P<0.05)具有统计学意义。结论马来酸曲美布汀联合双歧杆菌四连活菌片能有效治疗肠易激综合征。
Objective To study the clinical efficacy of Trimebutine maleate combined with Bifidobacterium tetanubacum in the treatment of irritable bowel syndrome. Methods A total of 117 patients with irritable bowel syndrome were randomly divided into treatment group (60 cases) and control group (57 cases). Treatment group trimebutine maleate 100mg, 3 times / d orally, bifidobacterium four live viable tablets 1.5g, 3 times / d orally; the control group only trimebutine maleate 100mg, 3 times / d orally. The course of treatment is 4 weeks. Results The total effective rate was 95.0 in the treatment group and 80.7 in the control group. The total effective rate in the treatment group was significantly better than that in the control group (P <0.05). Conclusion Trimebutine maleate combined with Bifidobacterium four live viable tablets can effectively treat irritable bowel syndrome.