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目的:应用植入式遥测技术,建立Beagle犬清醒动物呼吸和循环系统功能检测模型,应用遥测技术对Beagle犬生理参数进行长时程采集和分析,为临床前药物安全性评价试验提供重要的生理基础参考值。方法:通过外科手术,在Beagle犬体内埋植TL11M3-D70-PCTP遥测传感器,以DSI遥测生理信号采集系统连续记录并分析Beagle犬在无束缚条件下24 h生理信号,分析其昼夜节律,并以特非那定作为阳性药物进行验证。结果:成功建立了Beagle犬植入式清醒动物模型,Beagle犬的生理活动具有明显的昼夜节律性,早上09:00左右是多项生理指标的最高点,特非那定能够明显延长Beagle犬的QTc间期。结论:试验获得了本中心GLP试验室饲养条件下动物的基础值,可为其在药物临床前试验中的应用提供重要的参考数据。
OBJECTIVE: To establish a functional detection model of respiratory system and circulatory system in Beagle dogs by using implantable telemetry technology. Long-range acquisition and analysis of physiological parameters of Beagle dogs were conducted by telemetry to provide important physiological parameters for preclinical drug safety evaluation Basic reference value. Methods: The TL11M3-D70-PCTP telemetry sensor was implanted in Beagle dogs surgically. The physiological signals of Beagle dogs were recorded and analyzed with DSI telemetry system at 24 h. The circadian rhythm Terfenadine is tested as a positive drug. Results: Beagle dog was successfully established animal model of awake, Beagle dog physiological activity has a significant circadian rhythm, at about 09:00 morning is the highest point of a number of physiological indicators, terfenadine can significantly extend Beagle dogs QTc interval. Conclusion: The experiment obtained the basic values of animals under the GLP laboratory conditions in the center, which can provide important reference data for its application in the preclinical test of drugs.