电压门控性钾通道维持神经元静息膜电位,参与细胞兴奋性的改变。在三叉神经痛发病过程中,三叉神经节神经元作为初级感觉神经元,在痛觉的传导和传递过程中起重要作用。电压门控性钾通道的多种类型在三叉神经节神经元中均有表达,激活时产生不同类型的钾电流。电压门控性钾通道功能的改变,及其与多种神经递质、炎性介质和受体间的相互作用,在三叉神经痛的发病过程中起到了重要作用。 Voltage-gated potassium channels maintain neuronal resting membrane potential and are involved in changes in cell excitability. In the pathogenesis of trigeminal neuralgia, trigeminal ganglion neurons as primary sensory neurons play an important role in the process of conduction and transmission of pain. Various types of voltage-gated potassium channels are expressed in trigeminal ganglion neurons and produce different types of potassium currents upon activation. Changes in the function of voltage-gated potassium channels, as well as their interactions with various neurotransmitters, inflammatory mediators and receptors, play an important role in the pathogenesis of trigeminal neuralgia.