精氨酸(arginine)在人体内有营养支持、免疫防御及调节作用。精氨酸衍生物一氧化氮(NO)在肿瘤的发生、发展过程中具有重要作用,但其中的具体机制尚存许多争议。NO既可以刺激细胞免疫,抑制肿瘤生长,又能通过某些机制促进肿瘤生长,此双重作用依赖于局部的NO浓度、肿瘤的类型和肿瘤细胞对NO的敏感性等。 Arginine has nutritional support, immune defense and regulatory functions in the human body. The arginine derivative nitric oxide (NO) plays an important role in the carcinogenesis and progression of cancer, but the exact mechanism remains controversial. NO can stimulate cellular immunity, inhibit tumor growth, but also through some mechanisms to promote tumor growth, this dual role depends on the concentration of NO, the type of tumor and tumor cell sensitivity to NO.