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目的观察卡维地洛治疗扩张型心肌病合并心力衰竭的临床疗效。方法入选的30例扩张型心肌病患者在原有强心、利尿、扩血管等治疗基础加用卡维地洛,从3.125mg,开始2次/d,每2周剂量增加1倍,直至目标剂量12.5mg,2次/d,疗程6个月。治疗前后观察心功能,血压,心率,心脏超声,24h动态心电图及6min步行试验,评价药物疗效。结果卡维地洛治疗6个月后患者的心功能好转,血压,心率降低,6min步行试验距离增加,左室收缩舒张末期内径缩小,左室射血分数增加。结论长期服用卡维地洛可改善扩张型心肌病患者的心功能,提高运动耐量。
Objective To observe the clinical efficacy of carvedilol in the treatment of dilated cardiomyopathy with heart failure. Methods Thirty patients with dilated cardiomyopathy were treated with carvedilol on the basis of original cardioplegia, diuretic and vasodilator therapy, starting from 3.125 mg twice daily for 1 week and doubling every 2 weeks until the target dose 12.5mg, 2 times / d, treatment for 6 months. Before and after treatment, heart function, blood pressure, heart rate, echocardiography, 24-hour ambulatory electrocardiogram and 6-minute walk test were used to evaluate the efficacy of the drug. Results Carvedilol 6 months after the improvement of cardiac function, blood pressure, heart rate, 6min walking distance increased, left ventricular end-diastolic diameter narrowed, left ventricular ejection fraction increased. Conclusion Long-term use of carvedilol can improve cardiac function and improve exercise tolerance in patients with dilated cardiomyopathy.