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维生素D不仅在骨骼代谢及钙平衡中发挥着重要作用,而且具有免疫调节、抗炎及神经细胞保护功能等。这提示我们,VD在自身免疫性疾病如多发性硬化中可能发挥着重要的作用。流行病学调查及临床数据显示,低VD水平或VD代谢失调是诱发多发性硬化的危险因素之一。另有研究报道,VD血清浓度与多发性硬化的疾病活动和进展呈反相关。但是,这些数据并不是没有争议的,VD在多发性硬化治疗和预防中的作用还有着很多需要回答的问题。现有的以VD补充作为治疗MS措施的临床干预研究中得到的临床数据并不具备得出结论的能力,并且有些数据之间甚至是相互矛盾。
Vitamin D not only plays an important role in bone metabolism and calcium balance, but also has immunomodulatory, anti-inflammatory and nerve cell protection functions. This prompts us that VD may play an important role in autoimmune diseases such as multiple sclerosis. Epidemiological investigation and clinical data show that low VD levels or VD metabolic disorders are one of the risk factors inducing multiple sclerosis. Another study reported that VD serum concentration and multiple sclerosis disease activity and progress were inversely correlated. However, these data are not without controversy, and the role of VD in the treatment and prevention of multiple sclerosis still has many questions that need to be answered. Existing clinical data from clinical intervention studies that use VD supplementation as a treatment for MS measures do not have the ability to draw conclusions and some even conflict with each other.