,Metabolic reprogramming in cancer: the bridge that connects intracellular stresses and cancer behav

来源 :国家科学评论(英文版) | 被引量 : 0次 | 上传用户:Gsea
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Extensive changes in cellular metabolisms have been observed in cancer, They are probably induced by the same intracellular stressor, persistent off-balance in intracellular pH across possibly all adult cancers.It is these altered metabolisms that gives rise to a variety of cancerous behaviors such as continuous cell division, metastasis and drug resistance.
其他文献
期刊
Water naturallywets the pores of paper, causing the water to spontaneously wick into the paper.However, liquids do not wick into all porous materials.For exampl
期刊
青稞的分蘖能力与穗粒重是影响产量的重要因素。对这些因素之间关系的探讨很有必要。本文以目前我区大面积种植的品种及性状较优良的杂交亲本材料为对象,对不同熟期类型品种
Only two weeks ago, when the COVID-19 outbreak caused by the novel coronavirus, SARS-CoV-2 (previously named 2019-nCoV), started to look dangerous nationwide, w
期刊
The mechanical and thermal effects of the gigantic Tibetan Plateau (TP),together with its unique in situ land-air coupling and troposphere-stratosphere interact
期刊
Scientific exchange and collaboration between the two largest economies in the world are now facing serious challenges,due to isolationist policies of the Trump
期刊
Given the controversy regarding the Monsoon Melee,there is a need for more accurate Tibetan Plateau (TP) climate modeling that clarifies its role in monsoon var
期刊
In this editorial,we make the following points:The main threat of the new coronavirus (2019-nCoV,now officially named as SARS-CoV-2) may be its continual evolut
期刊
In the past century, we have witnessed the glorious achievements of control science in our daily life, such as industry, transportation, aeronautics and astrona
期刊
目的 利用基因工程方法重组表达神经突触结合蛋白Ⅰ的C2A片段,探讨其在心肌细胞凋亡显像中的应用价值.方法 (1)将C2A基因连接到含有谷胱甘肽转移酶(GST)的重组原核表达载体pGEX-6P-1上,转化感受态细菌BL21,异内基硫代半乳糖苷(IPTG)诱导后纯化.(2)用异硫氰酸荧光素(FITC)标记纯化的蛋白,通过细胞结合实验鉴定蛋白质活性.(3)采用2-亚氨基噻吩方法,进行99TcmO-4标记