作者(1983)进一步总结了生理模型的研究。除对原理略作阐述外,主要介绍应用情况。原文用表列出共37种物质的结构式、生物效应、文献来源、治疗应用、动物种属、动力学注解如限速因素、非线性动力学等(表略)。本文根据药物分类系统,并着重模型应用择要介绍于下。抗肿瘤药物放线菌素D:Lutz 等提出狗13室血流限速模型,发现细胞质量转运系数(Cell masstransfer coefficient)与血流速率属同一数量级,认为符合血流限速的假设。一个例外是睾丸室,血流速率远大于质量转运系数,提示与脑相似睾丸有较低的膜屏障,说明该室属膜限速。这一结果对睾丸肿瘤的治疗有重要意义。阿霉素:已建立兔、田鼠、小鼠及人的模型。兔模型分10室,曾用于模拟人血浆药物浓度,并与其实测值比较,发现24～48 h 间高估,而早期低估。Chan 等也曾采用该模型模拟人血药浓度,证明与正常患者结果相符;对某些肝 The author (1983) further summarized the study of physiological models. In addition to the principle of a little elaborate, the main application. The original text lists the structure of a total of 37 substances, biological effects, sources of literature, therapeutic applications, animal species, kinetic annotation such as speed-limiting factors, nonlinear dynamics (Table omitted). This article based on the drug classification system, and focus on the application of the model should be introduced in the next. The antitumor drug actinomycin D: Lutz et al. Proposed a model of dog blood flow restriction in 13 chambers. It was found that the cell mass transfer coefficient (Cmax) was the same order of magnitude as the blood flow rate and was considered to be consistent with the hypothesis of blood flow velocity. One exception is the testicular compartment, whose blood flow rate is much larger than the mass transit coefficient, suggesting that there is a lower membrane barrier in the testis that resembles the brain, indicating that the chamber is membrane-limited. This result is of great significance for the treatment of testicular tumors. Adriamycin: Rabbit, vole, mouse and human models have been established. The rabbit model was divided into 10 compartments and used to simulate human plasma drug concentration. Compared with the actual measured value, the rabbit model was overestimated between 24 and 48 h and underestimated early. Chan et al. Also used this model to simulate human plasma concentrations, demonstrating that they are consistent with normal patient outcomes; for some liver