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口服固体制剂的有效性,主要决定于药物的溶出和吸收二个过程。已知乙酰水杨酸是吸收迅速的药物之一,其通过人体胃肠壁的速度几乎与乙醇相等。因此,溶出速率便成了提高血药浓度,减低胃刺激作用的关键,从而引起了广泛的注意。1960年Levy等测定了8批商品乙酰水杨酸及其钙钠盐片和缓冲片的10分钟溶出量。指出药物的溶出速率与崩解时限并不相关,且不同产品间存在着显著差异。其后,Wagner等测定了76批不同片剂的崩解时限与溶出速率,其中包括复方乙酰水杨酸片。对该复方制剂采用了测定混合吸收度的方法,分别测定了不同时间的吸收度(At)及药物完全溶解时的吸收度(A∞),以At/A∞求得各时间的
The effectiveness of oral solid preparations, mainly depends on the dissolution and absorption of drugs two processes. Acetylsalicylic acid is known to be one of the most rapidly absorbed drugs and its rate of passage through the body’s gastrointestinal tract is almost equal to that of ethanol. Therefore, the dissolution rate has become the key to increasing plasma concentration, reducing gastric irritation, which attracted widespread attention. In 1960, Levy et al. Determined the 10-minute dissolution of eight batches of acetylsalicylic acid and its calcium sodium salt tablets and buffer tablets. Pointed out that the drug dissolution rate and disintegration time is not related, and there are significant differences between different products. Subsequently, Wagner et al. Determined the disintegration time and dissolution rate of 76 different tablets, including the compound acetylsalicylic acid tablets. The compound preparation was measured by the method of mixed absorbance was measured at different times of absorption (At) and the drug completely dissolved when the absorption (A ∞), with At / A ∞ obtained at each time