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目的:探讨2型糖尿病患者氧化型低密度脂蛋白抗体(oxldl),preptin水平的变化及其与糖尿病并发症的关系。方法:选择第四军医大学西京医院内分泌代谢科2011年5月至2011年10月住院2型糖尿病患者80例,其中男性53例,女性27例,对患者的慢性并发症检查结果进行评分(方法见下文),总分以5分为界,分为重度并发症40例,轻度并发症40例。正常对照组30例,其中男性17例,女性13例,均检测其血清preptin、anti-oxldl、hsCRP、血脂(lipid)、糖化血红蛋白(HbA1C)、尿微量白蛋白(MAU)、空腹血糖(FBS)、空腹胰岛素(Fins)等水平,并进行各指标之间的相关分析。结果:2型糖尿病患者血清anti-oxldl水平增高,preptin水平降低。二者无相关性。结论:高水平的anti-oxldl和低水平的preptin对糖尿病慢性并发症的发生发展可能有促进作用。
Objective: To investigate the changes of oxidized low density lipoprotein antibodies (oxLDL) and preptin in type 2 diabetic patients and its relationship with the complication of diabetes mellitus. Methods: Eighty patients with type 2 diabetes mellitus admitted to Xijing Hospital of the Fourth Military Medical University from May 2011 to October 2011 were selected, including 53 males and 27 females. The patients’ chronic complications were scored (Methods See below), the total score of 5 points for the community, divided into 40 cases of severe complications, 40 cases of mild complications. Normal control group of 30 patients, including 17 males and 13 females, were detected serum preptin, anti-oxldl, hsCRP, lipid, glycosylated hemoglobin (HbA1C), urine microalbumin (MAU), fasting blood glucose ), Fasting insulin (Fins) and other levels, and the correlation between the various indicators. Results: Serum levels of anti-oxldl increased and preptin levels decreased in type 2 diabetic patients. No correlation between the two. Conclusion: High levels of anti-oxldl and low levels of preptin may promote the development of chronic complications of diabetes.