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研制治疗消化性溃疡病的有效药物已重新引起注意,既发现新药,又对病因学的阐明进行了探讨。寻找新抗溃疡药的主要方向是致力于有效地抑制胃酸分泌,例如H_2受体阻滞剂。另一些值得重视的探索是涉及保护胃肠道,以防止有害物质损伤的药物。在这方面特别值得注意的是前列腺素及其同类物。H_2受体拮抗体作为治疗药物的西米替丁(甲氰咪胍;1)的空前成功,加速高效和高特异性的第二代H_2受体拮抗药的发展。关于在胃液中形成N-亚硝基甲氰咪胍和亚硝胺以及其可能诱发胃癌的争
The development of an effective drug for the treatment of peptic ulcer disease has drawn renewed attention, not only finding new drugs but also elucidating the etiology. The main directions for finding new anti-ulcer drugs are to focus on the effective inhibition of gastric acid secretion, such as H 2 blockers. Other explorations worthy of attention are those involving the protection of the gastrointestinal tract to prevent damage to harmful substances. Of particular note in this regard are prostaglandins and their analogues. The unprecedented success of cimetidine (Cimetidine; 1) as a H 2 receptor antagonist as a therapeutic drug accelerates the development of an efficient and highly specific second-generation H 2 receptor antagonist. Formation of N-nitrosoamidine and nitrosamines in gastric juice and their potential for inducing gastric cancer