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目的:了解反复呼吸道感染(RRI)患儿血微量元素与免疫功能水平的变化情况。方法:用原子吸收光谱法和免疫散射比浊法分别测定RRI患儿血中Fe、Cu、Zn、Ca、Mg含量和Ig G、Ig A、Ig M、C3、C4水平,并与健康儿童的相应指标进行对比分析。结果:RRI组血Fe、Zn、Ca含量和Ig A、Ig G水平均明显低于对照组(P<0.05);Cu、Mg含量和Ig M、C3及C4水平与对照组无显著性差异(P>0.05);各年龄组Fe、Zn、Ca缺乏比较,差异均无统计学意义(P<0.05)。结论:RRI患儿Zn、Fe、Ca含量降低和Ig A、Ig G水平下降可能是其易感因素,在RRI的防治中应注意及时合理地补充铁、锌及钙制剂和免疫球蛋白水平,维持体内的平衡,以提高抗感染能力,降低RRI的患病率。
Objective: To understand the changes of blood trace elements and immune function in children with recurrent respiratory tract infection (RRI). Methods: The levels of Fe, Cu, Zn, Ca, Mg and Ig G, Ig A, Ig M, C3 and C4 in blood of RRI children were determined by atomic absorption spectrometry and immune nephelometry. Corresponding indicators for comparative analysis. Results: The levels of Fe, Zn, Ca and Ig A and Ig G in RRI group were significantly lower than those in control group (P <0.05). There were no significant differences in Cu, Mg, Ig M, P> 0.05). There was no significant difference in Fe, Zn and Ca deficiency in all age groups (P <0.05). Conclusion: The decrease of Zn, Fe and Ca contents and the decrease of Ig A and Ig G in RRI children may be susceptible factors. In the prevention and treatment of RRI, we should pay attention to the timely and reasonable supplementation of iron, zinc and calcium preparations and immunoglobulin levels, Maintain the body’s balance to improve anti-infective ability and reduce the prevalence of RRI.