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为探讨葡萄籽提取物对小鼠的抗辐射保护作用,将50只昆明雄性小鼠随机分为辐射模型组、溶剂对照组、低(0.083 g/kg)、中(0.167 g/kg)、高(0.500 g/kg)剂量葡萄籽提取物组,用葡萄籽提取物灌胃25,25 d后除溶剂对照组外以7 Gy60Coγ射线对小鼠进行一次性全身照射,继续给予葡萄籽提取物灌胃7 d后,观察对小鼠红细胞超氧化物歧化酶(SOD)活力、肝组织中丙二醛(MDA)、肝组织中SOD的活力。结果显示,与辐射模型组比较,中、高剂量组红细胞SOD的活力上升(P<0.01),低、中、高剂量组肝组织中MDA含量下降(P<0.01),高剂量组肝组织中SOD活力上升(P<0.05),提示葡萄籽提取物对辐射所致小鼠氧化损伤具有拮抗作用。
To investigate the protective effect of grape seed extract on radiation protection in mice, 50 Kunming male mice were randomly divided into radiation model group, solvent control group, low (0.083 g/kg), medium (0.167 g/kg), and high. (0.500 g/kg) grape seed extract group, grape seed extract was used for intragastric administration for 25, 25 days and the whole body was irradiated with 7 Gy60Co γ-radiation in addition to the solvent control group and continued to give grape seed extract irrigation. Seven days after gastric cancer, the activities of superoxide dismutase (SOD) in red blood cells, malondialdehyde (MDA) in liver tissue, and SOD activity in liver tissue were observed. The results showed that compared with the radiation model group, the erythrocyte SOD activity was increased in the middle and high dose groups (P<0.01), and the MDA content in the liver tissues of the low, middle, and high dose groups was decreased (P<0.01). The activity of SOD increased (P<0.05), suggesting that grape seed extract has an antagonistic effect on radiation-induced oxidative damage in mice.