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CYP450氧化还原酶(POR)是所有肝微粒体的细胞色素P450氧化酶(CYP450)的唯一电子供体,负责甾醇激素、胆固醇、胆酸、维生素以及临床上超过80%药物的氧化代谢。POR本身具有高度的多态性,国内外报道显示POR基因的突变可使其本身活性或它与CYP450酶之间的相互作用发生改变,致使它与临床某些疾病的发生及某些药物体内代谢活性的改变密切相关。而POR基因多态性与CYP介导的药物代谢之间存在着CYP酶种类及底物的特异性,且国内相关研究相对较少。因此,我们通过对近年来POR基因多态性的临床研究进展进行综述,为今后相关研究及临床药物的个体化治疗提供参考。
CYP450 oxidoreductase (POR) is the only electron donor of cytochrome P450 oxidase (CYP450) of all liver microsomes responsible for the oxidative metabolism of sterols, cholesterol, bile acids, vitamins and clinically more than 80% of drugs. POR itself has a high degree of polymorphism, domestic and foreign reports show that mutations in the POR gene can make its own activity or its interaction with the CYP450 enzyme changes, resulting in the occurrence of certain clinical and clinical drug metabolism in vivo Changes in activity are closely related. The POR gene polymorphism and CYP-mediated drug metabolism exist between the CYP enzyme type and substrate specificity, and relatively few domestic research. Therefore, we review the progress of clinical research on POR gene polymorphism in recent years, and provide reference for future related research and individualized treatment of clinical drugs.