论文部分内容阅读
目的了解北京地区儿童病毒性脑炎的流行病学特点。方法对2002-01—2005-12在北京儿童医院住院治疗、出院诊断为病毒性脑炎的1016例进行回顾性总结分析,入选病例急性期血清和(或)脑脊液检测病毒IgM抗体,标本选择检测的病毒抗体种类按照临床医生的申请进行。结果1016例病毒性脑炎患儿占住院总人数的1.0%,男女比例为2.2∶1,年龄(6.4±4.0)岁。血清和(或)脑脊液病毒抗体阳性的病例共380例(38.5%),其中肠道病毒抗体阳性病例最多(44.7%),其次是流行性腮腺炎病毒(35.3%),单纯疱疹病毒(15.5%),风疹病毒(4.5%),乙型脑炎病毒(2.9%)。1016例中,有3例死亡。结论肠道病毒、流行性腮腺炎病毒和单纯疱疹病毒是北京地区儿童病毒性脑炎最常见的病原。该研究中62.6%的病例仍然缺乏病原学证据,因此需要建立针对更多病毒的快速敏感的检测方法从而为病毒性脑炎的诊断和治疗提供病原学证据。
Objective To understand the epidemiological characteristics of viral encephalitis in children in Beijing. Methods A total of 1016 patients diagnosed as viral encephalitis in Beijing Children’s Hospital from January 2002 to December 2005 were analyzed retrospectively. Virus IgM antibody was detected by serum and / or cerebrospinal fluid (CSF) The type of virus antibody according to the clinician’s application. Results A total of 1016 children with viral encephalitis accounted for 1.0% of the total number of hospitalizations, with a male-to-female ratio of 2.2:1 and a mean age of 6.4 ± 4.0 years. A total of 380 cases (38.5%) were positive for serum and / or CSFV antibodies, of which enterovirus positive was the most (44.7%), followed by mumps (35.3%), herpes simplex (15.5% ), Rubella virus (4.5%), Japanese encephalitis virus (2.9%). Of 1016 cases, 3 died. Conclusions Enterovirus, mumps and herpes simplex virus are the most common pathogen of childhood viral encephalitis in Beijing. 62.6% of the cases in this study still lacks the etiological evidence and therefore needs to establish a rapid and sensitive detection method for more viruses so as to provide etiological evidence for the diagnosis and treatment of viral encephalitis.