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目的考察红细胞免疫在大鼠皮肤及心脏移植后的变化情况及与其它细胞免疫指标变化的相关关系。方法在心脏移植前，Ａ组先用供体皮肤致敏，Ｂ组再于致敏前作供体抗原经胸腺耐受诱导，Ｃ组单纯作心脏移植，并于心脏移植围手术期动态测定红细胞免疫，在移植排斥高峰心脏停跳时测定迟发型超敏反应（ＤＴＨ）、淋巴细胞转化率变化。结果供体皮肤或心脏移植后，随时间推移，红细胞免疫花环率也上升，在排斥终点时达最高峰，而免疫耐受组升高不明显，其变化与ＤＴＨ及淋转率呈明显正相关关系。结论红细胞免疫能够间接反映皮肤及心脏移植后机体免疫状态，对预测移植后急性排斥有一定意义。
Objective To investigate the changes of erythrocyte immunity after skin and heart transplantation in rats and the correlation with other cellular immune parameters. Methods Before donor heart transplantation, group A was sensitized with donor skin. Group B was induced with thymic tolerance before donor sensitization. Group C was treated with heart transplantation only. Perioperative erythrocyte immunization , Late-onset hypersensitivity (DTH) and change in lymphocyte conversion were measured at graft rejection for peak cardioversion. Results After donor skin or heart transplantation, the rate of erythrocyte immunization rosette increased with the passage of time and reached its peak at the end of rejection, while the immune tolerance group did not increase significantly. The change was positively correlated with DTH and lymph node metastasis relationship. Conclusion Erythrocyte immunization indirectly reflects the immune status of the skin and heart after transplantation, which is of certain significance in predicting acute rejection after transplantation.