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石蒜碱能延长环己烯巴比妥钠、硫喷妥钠、水合氯醛等催眠剂原作用时间达2-4倍;能减少小鼠自发性活动,呈现明显的镇静作用;能增强延胡索乙素、吗啡等镇痛效力;能降低人工发热家兔体温;使乌拉坦麻醉兔尿量显著减少而呈抗利尿现象.通过大鼠条件反射及犬的呕吐反应证明,以3毫克与12毫克/公斤剂量水平的石蒜碱进行药理观察是适当的,前一剂量(3毫克/公斤)更具一定的实际意义.石蒜碱能抑制小鼠的呼吸代谢及肾脏琥珀酸脱氢酶的活力;降低兔心脏中ATP含量.大剂量抗坏血酸能增强石蒜碱的毒性.
Lycorine can prolong cyclohexene sodium, thiopental, chloral hydrate and other hypnotic agents of the original role of time 2-4 times; can reduce spontaneous activity in mice, showing significant sedation; can enhance the corydalis B and C, morphine and other analgesic effect; can reduce the artificial fever body temperature in rabbits; urethane anesthetize significantly reduced urinary output was anti-diuretic phenomenon by rat reflex and canine vomiting response to 3 mg and 12 mg / Kg dose of lycopene for pharmacological observation is appropriate, the former dose (3 mg / kg) more practical significance.Line garlic can inhibit respiratory metabolism and renal succinate dehydrogenase activity ; Reduce the ATP content in the rabbit heart.High dose of ascorbic acid can enhance the toxicity of Lycorine.