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以杂种犬各5只施行肾动脉主干及分支的无水乙醇灌注实验,灌注后分别于24、28小时、1周、2周、3周将灌注肾切取作病理检查:肾动脉及实质皆呈凝固性、完全性坏死,但组织结构及细胞轮廓长期不变。分支灌注者,坏死区与未坏死区之间有清楚界限,无移行关系。在临床曾对5例肾细胞癌、1例肾脓肿施行8次肾动脉主干及分支乙醇灌注,4例肾切除标本作了病理检查、2例巨大、晚期肾癌未能切除者,作半年以上的随访观察。以病理检查为基础的资料指出:无水乙醇肾动脉灌注可作为肾癌术前的常规措施,优于以往所用的其它肾动脉栓塞剂。
Five dogs in each of the mongrel dogs were subjected to ethanol perfusion experiments of the renal arteries and branches. Perfused kidneys were cut at 24, 28, 1, 2 and 3 weeks respectively for pathological examination: Coagulation, complete necrosis, but the long-term organizational structure and cell contour unchanged. Branch perfusion, there is a clear boundary between the necrotic area and the necrotic area, no migration relationship. In the clinic, 5 cases of renal cell carcinoma and 1 case of renal abscess were subjected to 8 times of renal artery trunk and branch ethanol perfusion. Four cases of nephrectomy were examined by pathology. Two cases of large and advanced renal cell carcinoma were unresectable for more than six months Follow-up observation. Pathological examination based on the data pointed out: anhydrous ethanol renal artery perfusion can be used as a routine measure of renal cell carcinoma before surgery, other renal artery embolization agent used in the past.