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目的探讨靶向微泡携带尿激酶联合低频超声完全溶栓后远端组织微循环再栓塞对血栓近段动脉弹性功能的影响。方法 37只新西兰大白兔成功制作单侧股动脉血栓模型,靶向微泡携带尿激酶联合低频超声辅助照射下溶栓并股动脉血栓完全融通,应用僵硬度定量检测技术及应变技术测量单侧兔股动脉血栓近段大动脉的扩张系数、顺应系数、弹性系数、僵硬度、脉搏波传导速度(pulse wave velocity,PWV)及动脉内膜收缩期径向应变、径向应变率。取兔腓肠肌组织标本行组织病理检查,HE染色观察组织末端血管微小血栓形成情况,根据组织病理结果将兔分为微循环再栓塞组11只和微循环未栓塞组26只。结果微循环再栓塞组血栓近段动脉PWV[(8.087±0.487)m/s]高于微循环未栓塞组[(6.855±0.317)m/s)](P<0.05);微循环再栓塞组血栓近段动脉扩张系数[(0.037±0.008)/kPa]、顺应系数[(0.037±0.012)mm~2/kPa]、径向应变[(0.156±0.071)/s]、径向应变率[(0.040±0.024)%]较微循环未栓塞组[(0.057±0.005)/kPa、(0.057±0.031)mm~2/kPa、(0.244±0.059)/s、(0.059±0.032)%]减小,微循环再栓塞组弹性系数(5.155±0.563)、僵硬度(10.560±1.133)较微循环未栓塞组(3.857±0.366、7.906±0.737)增大,但差异均无统计学意义(P>0.05)。结论动脉血栓完全融通后引起的远端组织微循环再栓塞可引起血栓近段动脉以PWV为主的弹性功能减退,测量动脉PWV对远端组织微循环再栓塞有一定预示意义。
OBJECTIVE: To investigate the effect of microtubule embolization with microbubbles combined with low-frequency ultrasonography on the elastic function of proximal thrombus in rabbits. Methods 37 New Zealand white rabbits were successfully established unilateral femoral artery thrombosis model, targeted microbubbles carrying urokinase combined with low-frequency ultrasound-assisted thrombolysis thrombolysis and femoral artery thrombosis complete communication, the application of quantitative measurement of stiffness and strain measurement of unilateral rabbits Coefficient of expansion, compliance coefficient, elastic coefficient, stiffness, pulse wave velocity (PWV), and radial strain and radial strain rate during arterial intimal thickening in proximal femoral artery thrombosis. Rabbit gastrocnemius muscle tissue samples were taken for histopathological examination. HE staining was used to observe the formation of microvascular thrombosis at the end of the tissue. According to histopathological results, the rabbits were divided into micro-circulation re-embolization group (n = 11) and micro-circulation non-embolization group (n = 26). Results The PWV of the proximal thrombus in the microcirculation re-embolization group was significantly higher than that in the non-embolization group [(6.855 ± 0.317) m / s) [(8.087 ± 0.487) m / s] (0.037 ± 0.08) / kPa], compliance coefficient [(0.037 ± 0.012) mm ~ 2 / kPa], radial strain [(0.156 ± 0.071) / s] and radial strain rate [( 0.040 ± 0.024)%] was less than that in the non-embolized group [(0.057 ± 0.005) / kPa, (0.057 ± 0.031) mm ~ 2 / kPa, (0.244 ± 0.059) / s, (0.059 ± 0.032)%] The elasticity coefficient (5.155 ± 0.563) and stiffness (10.560 ± 1.133) in microcirculation re-embolization group were significantly higher than those in microcirculation non-embolization group (3.857 ± 0.366,7.906 ± 0.737), but the difference was not statistically significant (P0.05) . Conclusions The reperfusion of distal tissue microcirculation caused by complete thawed arterial thrombosis may cause the PWV-based elastic function decline of the proximal thrombus artery. Measurement of arterial PWV has some predictive significance on distal tissue microcirculation re-embolization.