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作者通过临床标本及动物实验,观察胆汁中超氧化物歧化酶(SOD)、过氧化脂质(LPO)、β-葡萄糖醛酸苷酶(β-G)、总胆红素(TB)及总蛋白(P)等的变化,对胆道梗阻后胆汁中自由基反应及其在胆石形成中的作用进行了研究。结果发现:原发性肝胆管结石和/或胆道梗阻病人术中胆汁的SOD和LOP升高,显示自由基反应增强,切除病灶或解除梗阻后则逐渐下降。动物实验证明,兔胆道梗阻后,同样使胆汁中SOD和LPO显著上升,并伴随有组织性β-G,TB,及P的含量明显增加。组织性β-G和TB变化与SOD相关。提示胆道梗阻,胆管内压增高,可通过增强自由基反应途径使胆汁成份发生变化,导致胆石形成。
The authors observed superoxide dismutase (SOD), lipid peroxidation (LPO), β-glucuronidase (β-G), total bilirubin (TB) and total protein in bile through clinical specimens and animal experiments. Changes in (P) et al. studied the free radical reaction in bile after bile duct obstruction and its role in gallstone formation. The results showed that elevated bile SOD and LOP in patients with primary hepatolithiasis and/or biliary obstruction showed an increase in free radical response, and gradually decreased after removal of the lesion or removal of obstruction. Animal experiments showed that after biliary obstruction in rabbits, SOD and LPO in bile also increased significantly, and the content of organized β-G, TB, and P increased significantly. Changes in tissue β-G and TB are associated with SOD. Tip biliary obstruction, increased bile duct pressure, can enhance the free radical reaction pathway to make bile composition changes, resulting in gallstone formation.