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目的:探讨胎盘生长因子(PLGF)在上皮性卵巢癌中的表达及与卵巢癌发生、发展的关系和临床意义。方法:采用免疫组化方法,检测PLGF蛋白在52例卵巢癌原发灶、15例良性卵巢上皮性肿瘤及10例正常卵巢组织中的表达;结合病例的临床病理及预后资料,分析卵巢癌中PLGF蛋白表达的临床意义。结果:卵巢癌、良性卵巢上皮性肿瘤、正常卵巢组织中的PLGF过表达率分别为46.15%(24/52)、20.00%(3/15)与0%(0/10)。卵巢癌组的PLGF过表达率高于良性卵巢上皮性肿瘤组(P=0.027,OR=4.286,95%CIforOR:1.11~16.60)。PLGF蛋白过表达与卵巢癌分化程度密切相关,组织分化为G3级的卵巢癌病例其PLGF过表达率高于G1+G2级(P=0.012,OR=5.077,95%CIforOR:1.35~19.17)。PLGF过表达的卵巢癌病例其中位生存时间为34月,短于表达正常者的47月,差异具有统计学意义(Log Rank=4.887,P=0.008)。结论:在卵巢癌变过程中,PLGF过度表达水平随着卵巢病变程度的加重而上升,提示PLGF过度表达与卵巢肿瘤的发生相关;PLGF过度表达与卵巢癌恶性临床表型及不良预后密切相关。PLGF可能成为有效预测卵巢癌发生及预后的分子标记物。
Objective: To investigate the expression of placental growth factor (PLGF) in epithelial ovarian cancer and its relationship with the occurrence and development of ovarian cancer and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of PLGF protein in 52 cases of primary ovarian cancer, 15 cases of benign epithelial ovarian tumor and 10 cases of normal ovarian tissue. Combined with the clinical, pathological and prognostic data of cases, Clinical Significance of PLGF Protein Expression. Results: The overexpression rates of PLGF in ovarian cancer, benign epithelial ovarian tumor and normal ovarian tissue were 46.15% (24/52), 20.00% (3/15) and 0% (0/10), respectively. The overexpression of PLGF in ovarian cancer group was higher than that in benign ovarian epithelial tumor group (P = 0.027, OR = 4.286, 95% CI for OR: 1.11-16.60). The overexpression of PLGF protein is closely related to the differentiation of ovarian cancer. The overexpression of PLGF in tissue differentiated to G3 ovarian cancer was higher than that of G1 + G2 (P = 0.012, OR = 5.077, 95% CI for OR: 1.35-19.17). The median survival time of patients with PLGF overexpression was 34 months, which was shorter than that of 47 months patients with normal expression (Log Rank = 4.887, P = 0.008). CONCLUSION: The overexpression of PLGF increases with the severity of ovarian lesions during the carcinogenesis of ovarian cancer, suggesting that overexpression of PLGF is associated with ovarian cancer. The overexpression of PLGF is closely related to the malignant clinical phenotype and poor prognosis of ovarian cancer. PLGF may become a molecular marker for the effective prediction of the occurrence and prognosis of ovarian cancer.