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作者对15例多囊性卵巢病人进行了染色体分析。意外地发现14三体。核型分析是用改良胰蛋白酶钠-吉姆萨分带技术。15例正常妇女作对照组。每例数100只细胞,7~10只细胞进行了摄影及核型分析,并复习了临床病史、腹腔镜检查、内分泌检查及卵巢活检。结果:多数病人有月经过少,月经初潮延迟(例1、3、4、5、6、7、10、11、13、14、15),例2 18岁应用口服避孕药前无月经,服药2年后妊娠。例8规则月经3年(14~17岁)以后继发性闭经。例9在迁居至美国前(17岁)月经正常,以后月经不规则,由月经过少至月经过多。例12自12岁月经初潮后,每年有1~2次月经,其母和姑母也有类似病史。腹腔镜所见:除2例(例6、13)外均作了腹
The authors conducted a chromosomal analysis of 15 patients with polycystic ovarian disease. Unexpectedly found 14 trisomy. Karyotyping is performed using modified trypsin sodium-Giemsa zoning technique. 15 normal women as control group. Each case of 100 cells, 7 to 10 cells were photographed and karyotype analysis, and reviewed the clinical history, laparoscopy, endocrine examination and ovarian biopsy. Results: Most patients have less menarche, delayed menarche (cases 1,3,4,5,6,7,10,11,13,14,15), 2 cases of age 18 before the application of oral contraceptives without menstruation, medication 2 years after pregnancy. Example 8 rule 3 years after menstruation (14 to 17 years old) after secondary amenorrhea. Example 9 Before moving to the United States (17 years) normal menstruation, after irregular menstruation, from menorrhagia to menorrhagia. Example 12 since menstruation 12 years after menstruation 1 to 2 times a year, the mother and aunt also have similar medical history. Laparoscopic findings: In addition to two cases (cases 6,13) were made abdomen