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目的探讨~(125)I 粒子泪道探针治疗兔泪道狭窄的作用。方法制备兔双侧泪道狭窄模型,随机分成狭窄对照组、探通术治疗组和放射性探针(~(125)I 粒子)治疗组,每组10只。不作任何处理的5只新西兰纯种白兔作为空白对照组。探通术治疗组与放射性探针治疗组分别于治疗后10 min、30 d 及处死前60 min 行泪道数字减影(DSA)检查,所有动物处死后立刻进行泪道标本取材,HE 染色并用计算机图像分析仪测量泪道管腔面积。结果探通术治疗组与放射性探针治疗组治疗后10min,狭窄治愈率均为100%;2组治疗后10 min 与30 d 对比,再狭窄率分别为40%,10%。空白对照组、狭窄对照组、探通术治疗组、放射性探针治疗组泪道管腔面积分别为(0.84±0.28),(0.26±0.13),(0.55±0.31)和(0.80±0.36)mm~2。结论 ~(125)I 粒子泪道探针具有治疗泪道狭窄兼预防其发生再狭窄的作用。
Objective To investigate the role of ~ (125) I particle lacrimal probe in the treatment of rabbit lacrimal duct stenosis. Methods Rabbit bilateral lacrimal duct stenosis model was prepared and randomly divided into two groups: stenosis control group, probing group and radioactive probe (~ (125) I particle) group, 10 in each group. Five New Zealand purebred rabbits without any treatment served as blank control group. The results of digital subtraction (DSA) of lacrimal passage were observed at 10 min, 30 d and 60 min after the treatment respectively in the exploration group and radiotherapy group. All the animals were taken lacrimal specimens immediately after sacrifice, HE staining and Computerized image analyzer measures lacrimal duct lumen area. Results The cure rate of stenosis was 100% at 10 min after the treatment of radiotherapy and radiotherapy in the probe group. The restenosis rates were 40% and 10% in the two groups at 10 and 30 days respectively. The lacrimal lumen area of the blank control group, the stenosis control group, the exploration and treatment group and the radioactive probe treatment group were (0.84 ± 0.28), (0.26 ± 0.13), (0.55 ± 0.31) and (0.80 ± 0.36) mm ~ 2. Conclusion ~ (125) I particle lacrimal probe has the therapeutic effect on restenosis and prevention of restenosis.