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7903是一种新的胡椒碱衍化物,口服给药易从胃肠道吸收,作用出现快。大鼠口服后2小时已有较强的抗MES作用,4小时作用达高峰。有效时间持续较长,48小时作用才消失。 7903的抗惊厥作用较强;对多种急性和慢性实验性癫痫模型有不同程度的对抗作用,其中以对抗硫酸锌惊厥、MES和AS的作用最强;对抗戊四唑惊厥和谷氨酸钠惊厥次之。这些作用比其它胡椒碱衍化物强。 此外,7903还具有镇静作用和加强其它中枢抑制药的中枢抑制作用。
7903 is a new piperdine derivative, oral administration easily absorbed from the gastrointestinal tract, the role of fast. 2 hours after oral administration of rats have a strong anti-MES role, up to 4 hours peak. Effective duration of longer, 48 hours before disappearing. 7903 has a strong anticonvulsant effect; it has different antagonistic effects on a variety of acute and chronic experimental epilepsy models, with the strongest effect on the seizures of zinc sulfate, MES and AS; the antagonism of pentylenetetrazole convulsion and sodium glutamate Convulsive second. These effects are stronger than other piperdine derivatives. In addition, 7903 also has sedative effects and enhances the central inhibition of other central inhibitory drugs.