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目的 探讨炎性细胞因子 IL-8、IL-6在急性脑梗死免疫病理损伤中的作用。方法 用 ELISA法检测 4 5例急性期脑梗死患者血清 IL-8、IL-6水平 ,并与匹配年龄的 2 7例正常对照组比较。结果 急性期脑梗死组 IL-8水平为 ( 1 .39± 0 .1 1 ) ng/m L,IL-6检测阳性者为 4 6 .6 7% ,较正常对照组显著升高 (均 P<0 .0 0 1 )。相关性分析显示 ,脑梗死急性期 IL-8含量与梗死灶体积及神经功能缺失评分均呈直线正相关 ( r=0 .4 37,P<0 .0 0 5 ;r=0 .394 ,P<0 .0 1 ) ;血清 IL-6含量与梗死灶体积及神经功能缺损评分均呈等级正相关 ( rs=0 .4 6 7,P<0 .0 0 2 ;rs=0 .40 1 ,P<0 .0 1 )。结论 脑梗死急性期血清 IL-8、IL-6水平增高 ,且与梗死灶体积和神经功能缺损评分密切相关
Objective To investigate the role of inflammatory cytokines IL-8 and IL-6 in immunopathological damage of acute cerebral infarction. Methods Serum levels of IL-8 and IL-6 in 45 acute cerebral infarction patients were detected by ELISA, and compared with 27 matched normal controls. Results The level of IL-8 in acute cerebral infarction group was (1.39 ± 0.11) ng / m L, the positive rate of IL-6 was 46.76%, which was significantly higher than that in normal control group (all P <0 0 0 1). Correlation analysis showed that there was a linear positive correlation between IL-8 content and infarct volume and neurological deficit score in acute stage of cerebral infarction (r = 0.47, P <0.05; r = 0.394, P <0.01). Serum IL-6 level was positively correlated with infarct size and neurological deficit scores (rs = 0.4667, P0.002; rs = 0.401, P <0 .0 1). Conclusions The levels of IL-8 and IL-6 in the acute stage of cerebral infarction are increased, which are closely related to the infarct volume and neurological deficit score