法国马赛一家医院首次报告1例接种重组乙型肝炎疫苗引起血小板减少,调查表明有时间上联系,无服用其他药物和细菌或病毒感染史。此外,WHO国际药物监测协作中心还收到33例由肝炎疫苗引起的血小板减少病例的报告,其中乙型肝炎疫苗28例,甲型肝炎灭活疫苗5例。 28例乙型肝炎疫苗接种者中,6例血小板计数分别为12、13、15、60、87和130×10~9/L。有11例出现紫癜,8例血小板减少伴有其他症 A hospital in Marseilles, France, reported for the first time 1 case of thrombocytopenia caused by vaccination with recombinant hepatitis B vaccine. The survey showed that there was a time connection and no history of taking other drugs and bacterial or viral infections. In addition, WHO Collaborating Center on International Drug Surveillance also received 33 cases of thrombocytopenia caused by hepatitis vaccine cases, including 28 cases of hepatitis B vaccine, hepatitis A inactivated vaccine in 5 cases. Of 28 hepatitis B vaccinees, 6 had platelet counts of 12, 13, 15, 60, 87 and 130 × 10 ~ 9 / L, respectively. There are 11 cases of purpura, 8 cases of thrombocytopenia accompanied by other diseases