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目的观察复方苦参注射液联合斑蝥酸钠维生素B_6治疗鼻咽癌放射性口腔黏膜损伤的效果。方法将72例鼻咽癌放射性口腔黏膜损伤患者随机分为研究组和对照组各36例,均实施西医常规基础治疗,对照组加用斑蝥酸钠维生素B_6,研究组在对照组基础上给予复方苦参注射液治疗。对比2组治疗前后中医证候积分、口腔黏膜损伤分级变化、不同时刻VAS疼痛评分以及不良反应发生率。结果治疗后2组主症、次症和舌脉象、总积分、口腔黏膜损伤分级均明显改善(P均<0.05),且研究组改善情况均明显优于对照组(P均<0.05);治疗后2组VAS评分均随着治疗时间延长显著降低(P均<0.05),且治疗2周后和4周后研究组VAS评分均显著低于对照组(P均<0.05);2组不良反应发生率比较差异无统计学意义(P均>0.05)。结论复方苦参注射液联合斑蝥酸钠维生素B6治疗鼻咽癌放射性口腔黏膜损伤不仅可以改善中医证候,还可减轻口腔黏膜损伤和疼痛程度,值得推广应用。
Objective To observe the effect of compound Kushen injection combined with sodium cantharidinate vitamin B_6 in the treatment of radiation-induced oral mucosal injury in nasopharyngeal carcinoma. Methods 72 cases of nasopharyngeal carcinoma radioactive oral mucosal injury were randomly divided into study group and control group, 36 cases were treated with routine Western medicine, the control group with sodium cantharidinate vitamin B_6, the study group on the basis of the control group given compound Sophora injection treatment. The TCM syndrome scores, the classification of oral mucosal injury, VAS pain scores at different time points and the incidence of adverse reactions were compared between the two groups before and after treatment. Results After treatment, the main symptoms, secondary symptoms and tongue patterns, total score and oral mucosal lesion grading were significantly improved in both groups (all P <0.05), and the improvement in the study group was significantly better than that in the control group (all P <0.05) The VAS scores of the latter two groups were significantly decreased with the prolongation of treatment time (P <0.05), and the VAS scores of the two groups were significantly lower than those of the control group after 2 weeks and 4 weeks (all P <0.05) The incidence was no significant difference (P> 0.05). Conclusion Compound Kushen injection combined with sodium cantharidinate vitamin B6 in the treatment of nasopharyngeal radioactive oral mucosal injury can not only improve the TCM syndrome, but also reduce the degree of oral mucosal injury and pain, which is worth popularizing and applying.