论文部分内容阅读
目的：探讨肝硬变（ＬＣ）患者血清层粘连蛋白（ＬＭ）水平变化的影响因素及其临床意义．方法：应用放射免疫分析法测定６２例ＬＣ患者血清ＬＭ含量．结果：肝硬变患者血清ＬＭ［（１４８．７２±３６．５７）μｇ／Ｌ］，显著高于献血员对照组［（１０５．８１±１４．５６）μｇ／Ｌ，Ｐ＜０．０１］．Ｃｈｉｌｄ＇ｓＡ、Ｂ、Ｃ各级［（１２５．３５±３０．６２）μｇ／Ｌ，Ｐ＞０．０５；（１４５．６８±２７．９５）μｇ／Ｌ，Ｐ＜０．０１；（１７１．６５±４３．９９）μｇ／Ｌ，Ｐ＜０．０１］依次递增．ＬＣ患者血清ＬＭ与其血清胆红素、谷丙转氨酶含量有正相关性（ｒ＝０．３３９，ｒ＝０．２７２，Ｐ＜０．０１，Ｐ＜０．０５），与门静脉高压程度无明显相关（Ｐ＞０．０５）．结论：肝功能损害可能是肝硬变患者血清ＬＭ升高的重要原因．ＬＭ与门静脉高压无明显相关．
Objective: To investigate the influencing factors of serum laminin (LM) level in patients with cirrhosis (LC) and its clinical significance. Methods: The contents of serum LM in 62 patients with LC were determined by radioimmunoassay. Results: The serum LM [(148.72 ± 36.57) μg / L] in cirrhotic patients was significantly higher than that in blood donors [(105.81 ± 14.56) μg / L, P <0.01] . (125.35 ± 30.62) μg / L, P> 0.05; (145.68 ± 27.95) μg / L, P <0.01 for Child’sA, B, .65 ± 43.99) μg / L, P <0.01] in ascending order. There was a positive correlation between serum LM and serum bilirubin and alanine aminotransferase in patients with LC (r = 0.339, r = 0.272, P <0.01, P <0.05) and no significant correlation with portal hypertension Related (P> 0.05). Conclusion: Impaired liver function may be an important reason for elevated serum LM in cirrhotic patients. LM and portal hypertension had no significant correlation.