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目的分析2型糖尿病(T2DM)患者合并胆结石的危险因素。方法采用回顾性分析方法,分别测定83例T2DM伴胆结石组患者与127例T2DM不伴胆结石组患者的血清胰岛素、C肽、血脂水平,计算胰岛素敏感指标(ISI),并进行差异性比较。结果伴胆结石组患者空腹血清胰岛素、C肽较不伴胆结石组显著增高(P<0.05),而ISI明显降低(P<0.05),血清总胆固酸、甘油三酯水平两组间无明显差异(P>0.05),但伴胆结石组的高密度脂蛋白胆固醇水平较不伴胆结石组低(P<0.05),而低密度脂蛋白胆固醇及载脂蛋白B水平显著增高(P<0.05)。结论高胰岛素血症、脂代谢紊乱可能是2型糖尿病合并胆结石的危险因素。
Objective To analyze the risk factors of gallstone in type 2 diabetes mellitus (T2DM). Methods The levels of serum insulin, C-peptide and lipids in 83 patients with T2DM with gallstone and 127 patients with T2DM without gallstone were measured by retrospective analysis. The insulin sensitivity index (ISI) was calculated and compared. . Results The fasting serum insulin and C-peptide in patients with gallstones were significantly higher than those without gallstone (P <0.05), while ISI was significantly lower (P <0.05). There were no significant differences in serum total cholesterol and triglyceride between the two groups (P> 0.05). However, the levels of high density lipoprotein cholesterol in patients with gallstone were significantly lower than those without gallstone (P <0.05), while the levels of low density lipoprotein cholesterol and apolipoprotein B were significantly increased (P < 0.05). Conclusions Hyperinsulinemia and dyslipidemia may be the risk factors of type 2 diabetes with gallstone.