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目的:探讨妊娠期甲状腺功能筛查和临床治疗的效果。方法:选取2015年1月-2016年6月在医院进行甲状腺功能筛查的580例孕20周前产妇作为研究对象,记录患者的游离甲状腺素(FT4)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3),并回顾性分析50例患有妊娠期亚临床甲状腺功能减退患者应用左旋甲状腺素进行治疗的临床效果。结果:本次研究的580例孕妇中,促甲状腺激素腺激素平均浓度为(1.68±0.25)m U/L,血清中甲状腺素平均浓度为(66.5±3.1)μg/dl。其中共有50例孕妇患有亚临床甲状腺功能减退,该疾病发生率为8.62%;两组患者在早产、羊水少、妊娠期糖尿病、产后出血等并发症发生率间比较,组间无明显差异(P>0.05),但观察组孕妇在胎儿受限和胎儿窘迫等并发症发生率低于对照组,组间差异具有统计学意义(P<0.05)。结论:在孕妇产检中加强甲状腺功能筛查,并给以亚临床甲状腺功能减退孕妇应用药物进行治疗,降低妊娠期并发症发生率。
Objective: To investigate the effect of thyroid function screening and clinical treatment during pregnancy. Methods: A total of 580 pregnant women and 20 weeks pregnant women with thyroid function screening from January 2015 to June 2016 in our hospital were selected as research objects. The levels of free thyroxine (FT4), thyrotropin (TSH), free tri (FT3), and retrospectively analyzed the clinical effect of 50 cases of subclinical hypothyroidism during pregnancy treated with L-thyroxine. Results: The average thyrotropin-stimulating hormone concentration was (1.68 ± 0.25) mU / L in 580 pregnant women in this study, and the average serum thyroxine concentration was (66.5 ± 3.1) μg / dl. A total of 50 pregnant women with subclinical hypothyroidism, the incidence of the disease was 8.62%; two groups of patients with preterm birth, oligohydramnios, gestational diabetes, postpartum hemorrhage and other complications between the comparisons, no significant difference between groups ( P> 0.05). However, the incidences of complications such as fetal restriction and fetal distress in the observation group were lower than those in the control group. The differences between the two groups were statistically significant (P <0.05). Conclusion: The screening of thyroid function is strengthened during pregnancy test, and pregnant women with subclinical hypothyroidism are treated with drugs to reduce the incidence of complications during pregnancy.