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本文应用斑点杂交试验直接检测101例乙肝病毒(HBV)无症状携带者、慢活肝及肝硬化患者血清HBV DNA,阳性率分别为58.3％(21/36)、36.9％(17/46)、10.5％(2/21),三组间有显著差异(P<0.01)。并与血清免疫标志进行比较,在HBeAg阳性时,HBV DNA检出率分别为95.2％(20/21)、70.8％(17/24)、25.0％(1/4),三组间有显著差异(P<0.05)。HBsAg、抗-HBc及抗-HBe与血清HBV DNA并非一致。结果表明,HBV无症状携带者比慢活肝及肝硬化具有更高的传染性,是极重要的传染源。
In this study, we detected the serum HBV DNA of 101 patients with asymptomatic carriers of hepatitis B virus (HBV), chronic hepatitis and cirrhosis by dot blot hybridization test. The positive rates of serum HBV DNA were 58.3% (21/36), 36.9% (17/46) 10.5% (2/21), there was a significant difference among the three groups (P <0.01). Compared with the serum immunological markers, the detection rates of HBV DNA were 95.2% (20/21), 70.8% (17/24) and 25.0% (1/4) respectively in HBeAg positive group. There was significant difference among the three groups (P <0.05). HBsAg, anti-HBc and anti-HBe are not the same as serum HBV DNA. The results show that asymptomatic carriers of HBV than the slow liver and liver cirrhosis have a higher contagious, is a very important source of infection.