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目的:研究大黄对急性胰腺炎的治疗作用。方法:应用逆行胆管注射3%牛黄胆酸钠诱导大鼠急性胰腺炎,分别于造模后6、12、24 h观察大鼠的死亡率,胰腺系数,血清中淀粉酶(AMY)、超氧化物歧化酶(SOD)、TNF-α和IL-1β含量,并对胰腺进行病理学检测。结果:与模型组比较,各时间点给药组的死亡率、胰腺质量、血清TNF-α和IL-1β含量均显著降低(P<0.05),血清SOD活性显著升高(P<0.01);给药组AMY含量于造模后6 h时显著低于模型组(P<0.01)1,2 h时显著高于模型组(P<0.01)2,4 h时两者未见统计学差异(P>0.05);各给药组病理得分与模型组相比均显著降低,但得分增高的趋势类似。结论:大黄对模型动物的胰腺病变有保护作用,但不能逆转其变化趋势。
Objective: To study the therapeutic effect of rhubarb on acute pancreatitis. Methods: Acute pancreatitis was induced by injection of 3% sodium taurocholate in rats with retrograde bile duct. The rats were sacrificed at 6, 12, and 24 hours after modeling to observe the mortality, the pancreatic coefficient, the amylase in serum (AMY) The contents of SOD, TNF-α and IL-1β were measured and the pathological changes of pancreas were observed. Results: Compared with model group, the mortality, the quality of pancreas, the level of serum TNF-α and IL-1β were significantly decreased (P <0.05) and the activity of SOD in serum were significantly increased at each time point (P <0.01). The level of AMY in the treated group was significantly lower than that in the untreated group (P <0.01) at 1 h and 6 h (P <0.01), but no significant difference was found between the two groups P> 0.05). The pathological score of each administration group was significantly lower than that of the model group, but the trend of increasing score was similar. Conclusion: Rhubarb has a protective effect on pancreatic lesions of model animals, but it can not reverse its changing trend.