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2 抗乙肝病毒药物 现有的抗乙肝病毒药物主要作用于cccDNA以下的复制阶段,如α-干扰素、核苷类似物、氧化苦参碱等。 2.1干扰素治疗乙肝 干扰素主要分为α、β、γ三种,抗肝炎病毒有效的是α和β,它们可结合于同一种细胞,干扰受体的不同侧面位点。作用相似,IFN-β抗病毒作用不如IFN-α,所以已很少使用。关于IFN-α的亚型,已发现有20多种,临床上常用的有IFNα -1b、IFNα-2b、IFNα2a、复合IFNα-Co1,皆为基因产品,白细胞生产的干扰素已被
2 anti-hepatitis B virus drugs Existing anti-hepatitis B virus drugs mainly in the cccDNA replication stage below, such as α-interferon, nucleoside analogues, oxymatrine and so on. 2.1 Interferon treatment hepatitis B interferon is mainly divided into three kinds of α, β, γ, anti-hepatitis virus effective α and β, they can be combined in the same cell, interfering with the different side of the receptor site. Similar effects, IFN-β antiviral effect than IFN-α, it has been rarely used. About the subtypes of IFN-α, more than 20 kinds of IFN-α have been found, commonly used clinically IFNα-1b, IFNα-2b, IFNα2a, complex IFNα-Co1, are all gene products, leukocyte production of interferon has been