作者从Lesch-Nyhan综合征病人冻干细胞沉淀物内测出酶活性增高,作者研究这些冻干细胞抽出物是否也刺激生长着的HPRT(次黄嘌呤-鸟嘌呤磷酸核糖苷转移酶)突变型宿主细胞结合次黄嘌呤作用。本文就表型相互作用对培养的HPRT突变型细胞——该细胞经正常细胞和HPRT突变型细胞抽出物预温——的影响,以及正常细胞的冻干沉淀物对正常细胞次黄嘌呤结合影响,加以比较研究。HPRT突变病人和健康对照者的皮肤活 The authors tested increased enzyme activity in lyophilized cell pellets from patients with Lesch-Nyhan syndrome, and the authors investigated whether these lyophilized cell extracts also stimulate the growing HPRT (hypoxanthine-guanine phosphoribosyltransferase) mutant host cells Combined with hypoxanthine effect. In this article, the effect of phenotypic interaction on cultured HPRT mutant cells, pre-warmed by normal cells and HPRT mutant cell extracts, and the effect of normal cells lyophilized on hypoxanthine binding , To be comparatively studied. HPRT mutations in the skin of patients and healthy controls