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目的:研究珍珠滴丸的组方合理性。方法:以大鼠口腔黏膜溃疡愈合的药效学试验为评价指标,通过正交实验的交互作用和方差分析,探讨组方中各药味的主次及相互关系,用正交t值法实验设计进行处方配比研究。结果:各药物在珍珠滴丸组方中的重要性地位依次为:羊耳菊>甘草>冰片>珍珠;冰片与珍珠之间具有明显的交互作用,且4药合用具有协同效果;处方中羊耳菊、甘草、珍珠和冰片的比例为100∶20∶2∶1。结论:通过对组方及配比的合理性研究,确定了组方配比,同时验证了该方民间用药的合理性。
Objective: To study the rationality of the composition of pearl dropping pills. METHODS: The pharmacodynamics test of oral ulcer healing in rats was used as evaluation index. The interactions and variance analysis of orthogonal experiments were used to explore the primary and secondary relationship of each drug in the formulation. The experimental design was performed using orthogonal t value method. Formulation ratio study. RESULTS: The importance status of each drug in the Pearl Drop Pill group was as follows: Chrysanthemum> Licorice> Borneol> Pearl; There was a clear interaction between the borneol and the pearl, and 4 drugs had a synergistic effect; The ratio of chrysanthemums, licorice, pearls, and borneol is 100:20:2:1. Conclusion: Through the study of the rationality of the prescription and matching ratio, the matching ratio of the prescription was determined, and the rationality of the folk medicine of the party was also verified.