实验观察了甲苯噻嗪对丁卡因毒性的影响,结果表明,经小白鼠ip甲苯噻嗪2mg/kg及8mg/kg,安定2.5mg/kg,iv甲苯噻嗪2mg/kg及4mg/kg,安定 2.5mg/kg均能预防丁卡因的毒性作用,降低其死亡率;甲苯噻嗪2mg/kg,安定2.5mg/kg对此毒性,尚有治疗作用,与生理盐水对照组比较,有非常显著性差异(P<0.01);甲苯噻嗪1mg/kg,安定2.5mg/kg耳静脉注射,能明显增加家兔对丁卡因的耐受量。 The effect of xylazine on the tetracaine toxicity was observed experimentally. The results showed that the effects of xylazine on the toxicity of tetracaine were observed. The mice were anesthetized with xylazine 2mg / kg and 8mg / kg, diazepam 2.5mg / kg, iv xylazine 2mg / kg and 4mg / kg, Diazepam 2.5mg / kg can prevent tetracaine toxicity and reduce its mortality; xylazine 2mg / kg, stability and 2.5mg / kg of this toxicity, there is a therapeutic effect, compared with the saline control group, there is a very Significant difference (P <0.01); xylazine 1mg / kg, diazepam 2.5mg / kg ear vein injection, can significantly increase the rabbit tolerance to tetracaine.