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本文测定30例原发性肝癌患者及30例健康成人红细胞内脂质过氧化物(LPO)含量、超氧化物歧化酶(SOD)活性及谷胱甘肽过氧化酶(GSH-PX)活性。结果显示,原发性肝癌患者红细胞LPO含量较正常对照组明显升高,P<0.001;红细胞SOD活性及GSH-PX活性均较正常对照组明显降低,均为P<0.001。在单纯型肝癌及肝癌伴有肝硬化者两种类型之间,红细胞LPO含量、SOD及GSH-PX活性三项指标均无显著性差异,均为P>0.05。提示:(1)自由基及脂质过氧化物导致的细胞损害可能是原发性肝癌发病的机制之一;(2)原发性肝癌患者体内脂质过氧化强度与是否伴有肝硬化无关。
The content of lipid peroxide (LPO), activity of superoxide dismutase (SOD) and activity of glutathione peroxidase (GSH-PX) in erythrocytes of 30 patients with primary liver cancer and 30 healthy adults were measured. The results showed that the content of red blood cell LPO in primary liver cancer patients was significantly higher than that in the normal control group, P<0.001; the activity of red blood cell SOD and GSH-PX activity was significantly lower than that in the normal control group, both were P<0.001. There were no significant differences in LPO content, SOD, and GSH-PX activity between simplex liver cancer and liver cancer patients with cirrhosis. Both were P>0.05. Tips: (1) Cell damage caused by free radicals and lipid peroxides may be one of the mechanisms of the onset of primary liver cancer; (2) The lipid peroxidation intensity in patients with primary liver cancer is not associated with cirrhosis. .