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目的观察芬太尼透皮贴剂治疗鼻咽癌患者放射性口腔黏膜损伤所致疼痛的疗效。方法对56例使用芬太尼透皮贴剂治疗鼻咽癌同期放化疗中出现放射性口腔黏膜中重度疼痛的患者采用自身对照方式,比较治疗前后患者疼痛缓解情况及不良反应。结果本组56例患者中,总有效率为100.0%,镇痛疗效显著,无1例因不良反应停药。患者用药后疼痛缓解程度:初始剂量25μg/h,治疗总有效率为75.0%,其中MR 14例;剂量增加到50μg/h后,治疗总有效率为78.6%,其中MR 3例;剂量增加到75μg/h后,总有效率为100.0%。主要不良反应为恶心、呕吐、头晕、头痛、便秘、嗜睡。结论芬太尼透皮贴剂可有效缓解鼻咽癌同期放化疗患者口腔黏膜疼痛,具有方便、无创、镇痛效果好、不良反应小等优点,明显改善了患者的生存质量,值得临床上应用。
Objective To observe the efficacy of transdermal fentanyl in the treatment of nasopharyngeal carcinoma patients with radiation-induced oral mucosal lesion pain. Methods Fifty-six patients with severe oral radioactive mucosa pain during concurrent chemoradiotherapy of nasopharyngeal carcinoma were treated with fentanyl transdermal patch in 56 patients, and their pain relief and adverse reactions were compared before and after treatment. Results 56 patients in this group, the total effective rate was 100.0%, analgesic effect was significant, no one due to adverse drug withdrawal. The patient’s pain relief after treatment: the initial dose of 25μg / h, the total effective rate was 75.0%, of which 14 cases of MR; dose increased to 50μg / h, the total effective rate was 78.6%, of which MR 3 cases; After 75μg / h, the total effective rate was 100.0%. The main adverse reactions were nausea, vomiting, dizziness, headache, constipation, lethargy. Conclusions Fentanyl transdermal patch can effectively relieve the oral mucosal pain in patients with nasopharyngeal carcinoma during concurrent chemoradiotherapy. It has the advantages of convenience, non-invasiveness, good analgesic effect and small adverse reaction, and obviously improves the quality of life of patients, which is worthy of clinical application .