在人类口腔中存在着种类繁多的天然菌群,这些细菌以牙菌斑生物膜的形式生长。菌斑生物膜作为人类龋病和牙周病的主要致病因素,有诸多代谢特点和生理现象明显不同于浮游态的细菌。下面就数种主要的口腔致病菌在生物膜状态和浮游态下的特性,如对抗菌剂的敏感性、基因表达和信号传导、耐酸性等方面的研究进展作一综述。 There is a wide variety of natural flora in the human oral cavity that grows in the form of plaque biofilms. Plaque biofilms as the main causal factor of human caries and periodontal disease, there are many metabolic characteristics and physiological phenomena were significantly different from the floating state bacteria. The following are some of the major oral pathogenic bacteria in the biofilm state and the characteristics of floating state, such as the sensitivity of antibacterial agents, gene expression and signal transduction, acid resistance and other research progress are reviewed.