论文部分内容阅读
目的:探讨硝苯地平联合硫酸镁对高龄孕妇妊娠高血压的临床疗效及可能机制。方法:收集我院高龄孕妇妊娠高血压患者54例,随机分为A组和B组,各27例。A组给予100 m L 5%葡萄糖注射液加入20 m L 25%的硫酸镁注射液静脉滴注,30 min内滴完;再给予500 m L 5%葡萄糖注射液加入40 m L 25%硫酸镁注射液1~2 g/h,静脉滴注;B组在A组用药的基础上给予给予硝苯地平控释片30 mg/次口服,1次/日,2组患者均治疗7 d。治疗结束后,比较两组患者血压、C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)及蛋白尿水平。结果:与治疗前相比,两组患者治疗后收缩压、舒张压、CRP、IL-6、TNF-α及蛋白尿水平均显著降低(P<0.05);与A组比较,B组患者收缩压、舒张压、CRP、IL-6、TNF-α及蛋白尿水平较低(P<0.05)。结论:硝苯地平联合硫酸镁对高龄孕妇妊娠高血压有较好的临床疗效,推测其机制与降低CRP、IL-6及TNF-α水平有关。
Objective: To investigate the clinical effect of nifedipine combined with magnesium sulfate on pregnancy-induced hypertension in pregnant women and its possible mechanism. Methods: 54 pregnant women with pregnancy-induced hypertension in our hospital were randomly divided into group A and group B, with 27 cases in each group. Group A was given 100 m L 5% glucose injection by adding 20 m L of 25% magnesium sulfate injection intravenously, dropping within 30 min; then adding 500 m L 5% glucose injection 40 m L 25% magnesium sulfate Injection 1 ~ 2 g / h, intravenous infusion; Group B was given on the basis of group A to give nifedipine 30mg / dose orally, 1 / day, 2 patients were treated for 7 days. After treatment, blood pressure, C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and proteinuria were compared between the two groups. Results: Compared with those before treatment, systolic blood pressure, diastolic blood pressure, CRP, IL-6, TNF-α and proteinuria were significantly decreased in both groups (P <0.05) Pressure, diastolic blood pressure, CRP, IL-6, TNF-α and proteinuria were lower (P <0.05). Conclusion: Nifedipine combined with magnesium sulfate has a good clinical effect on pregnancy-induced hypertension in pregnant women. It is speculated that the mechanism of nifedipine and magnesium sulfate is related to the decrease of CRP, IL-6 and TNF-α.