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目的 目前发现催乳素 (PRL)与缺氧缺血性脑病 (HIE)的严重程度密切相关 ,PRL与新生儿窒息的关系较少报道 ,该文探讨窒息新生儿母儿血浆催乳素 (PRL)水平变化与相关性及其意义。方法 采用放射免疫分析法对 2 5例围产期窒息新生儿 (窒息组 ,其中轻度窒息 1 4例 ,重度窒息 1 1例 )及 2 0例正常新生儿 (对照组 )母血、脐血及新生儿血浆PRL水平进行测定并进行动态观察。结果 窒息组母血、脐血及新生儿血浆PRL水平[(36 2 .5± 1 2 7.1 ) ,(984 .6± 2 6 2 .3) ,(386 .3± 2 1 6 .2 ) μg/L]均显著高于对照组 [(96 .4± 2 6 .2 ) ,(92 .3± 1 8.4 ) ,(6 8.7± 7.2 7) μg/L](P均 <0 .0 1 ) ;重度窒息组母血、脐血及新生儿血浆PRL水平 [(4 4 5± 2 1 6 ) ,(996± 2 84 ) ,(4 1 2± 2 2 1 ) μg/L]均高于轻度窒息组 [(2 98± 1 0 2 ) ,(6 1 2± 2 2 1 ) ,(30 9±1 9.2 ) μg/L](P <0 .0 1或 0 .0 5 )。轻、重度窒息组中脐血与新生儿血浆PRL水平具有显著的正相关关系 (r =0 .5 4 ,0 .6 3,P <0 .0 5 )。窒息新生儿复苏后血浆PRL水平高于对照组 (P <0 .0 1 ) ;生后第 2天PRL水平逐渐下降 ,但仍高于对照组 (P <0 .0 5 ) ;生后第 1 0天血浆PRL水平与对照组差异无显著性 (P >0 .0 5 )。结论 围产期窒息时新生儿血浆
OBJECTIVE: To investigate the relationship between PRL and the severity of hypoxic-ischemic encephalopathy (HIE), and the relationship between PRL and neonatal asphyxia is seldom reported. In this paper, the level of plasma prolactin (PRL) Change and Relevance and Their Significance. Methods Radioimmunoassay (RIA) was used to evaluate the effects of maternal blood, umbilical cord blood and blood pressure on 25 neonates with perinatal asphyxia (asphyxia group, 14 with mild asphyxia, 11 with severe asphyxia) and 20 normal neonates (control group) And neonatal plasma PRL levels were measured and observed dynamically. Results The level of PRL in maternal blood, umbilical cord blood and newborn infants in asphyxia group was significantly higher than that in non-asphyxia group (36 2 .5 ± 1 12.1), (984 .6 ± 2 6 2 .3), (386.3 ± 2 1 6. 2) / L] were significantly higher than those in the control group [(96.4 ± 26.2), (92.3 ± 8.4), (6.78 ± 7.27) μg / L] (all P <0.01) ; PRL levels in maternal serum, umbilical blood and newborn children in severe asphyxia group were significantly higher than those in mild asphyxia group [(445 ± 2166), (996 ± 284), (4112 ± 2121) μg / L] Degree of asphyxia group [(2 98 ± 1 0 2), (6 1 2 ± 2 2 1), (30 9 ± 1 9.2) μg / L] (P 0 01 or 0 0 5). There was a significant positive correlation between cord blood and plasma PRL levels in mild and severe asphyxia group (r = 0.54, 0.636, P <0.05). PRL levels in neonates with asphyxia after resuscitation were significantly higher than those in control group (P <0.01); PRL levels decreased on the second day after birth, but still higher than those in control group (P <0.05) There was no significant difference in plasma PRL level between the 0th day and the control group (P> 0.05). Conclusions Perinatal asphyxia newborn plasma